fusobacterium nucleatum subsp. nucleatum knorr  (ATCC)

Journal: Microorganisms

Article Title: In Vitro Inhibition of Pathogens by Polyols: Optical Density-Based Screening and Implications for the Oral–Systemic Axis

doi: 10.3390/microorganisms14040884

Figure Lengend Snippet: Endpoint OD600 of Fusobacterium nucleatum at 25.5 h across polyol concentrations. Bars show mean ± SD ( n = 3). Different letters within a concentration indicate Tukey’s HSD groupings ( p < 0.05). The dashed line indicates the untreated control mean. The untreated control mean OD was 1.070 +/− 0.485, whereas that of erythritol 1% was 1.823 +/− 0.163 and that of erythritol 2% was 1.413 +/− 0.374; for D-mannose 1%, the mean OD was 1.577 +/− 0.091, and for D-mannose 2%, it was 1.427 +/− 0.087.

Article Snippet: The following microorganisms were evaluated: Streptococcus mutans (ATCC 25175), Streptococcus anginosus (ATCC 700231), Candida albicans (ATCC 18804), and Fusobacterium nucleatum subsp. nucleatum (ATCC 23726).

Techniques: Concentration Assay, Control

Journal: medRxiv

Article Title: Integrative Genomic, Transcriptomic, and Microbiome Profiles of Colon Cancer by Ancestry Provide Insights into Molecular Distinctions

doi: 10.64898/2026.03.25.26349226

Figure Lengend Snippet: A) Alpha diversity (Observed richness, Shannon index) in tumor vs. non-tumor samples (n = 32, 31), and tumors stratified by location (right, n = 16; left, n = 16) or stage (early, n = 22; late, n = 10). B) Differential abundance analysis at the species level comparing tumor vs non-tumor (left), right vs left tumor (middle), and early vs late stage tumor (right). Volcano plots highlight significantly enriched taxa (FDR < 0.05). C) Phylum-level taxonomic composition in tumor and non-tumor tissues, showing enrichment of Fusobacteriota in tumors. D) Genus-level composition of tumors stratified by Fusobacterium nucleatum detection by qPCR (positive vs. negative). E) Top species enriched in tumors from African (AFRg) and European (EURg) ancestry patients (n = 68, WGS); dot size reflects significance (–log10 FDR); colors denote ancestry specificity (red = AFR only, purple = shared). F) Oral-origin taxa significantly enriched in tumors based on presence/absence data and annotation using the Human Oral Microbiome Database (HOMD v16.01). Bar length indicates log2 odds ratio of presence in tumor vs non-tumor (Fisher’s exact test). 16S rRNA sequencing was performed in a sub-cohort of 32 patients (A–D), and WGS in 68 patients (E–F) from the P-1000 cohort.

Article Snippet: For absolute quantification, microbial genomic DNA of F. nucleatum subsp. nucleatum strain VPI 4355 (ATCC # 25586D-5) was used to prepare the standard curve and as a positive control; the negative control was sterile H 2 O.

Techniques: Sequencing